BP405T

Systemic Pharmacology I (Theory)

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UNIT 1

Pharmacology of drugs acting on the peripheral nervous system a) Organization and functions of PNS. b) Neurohumoral transmission, co-transmission. Neurotransmitters and their receptors, including non-adrenergic and non-cholinergic (NANC) neurotransmitters. c) Parasympathomimetic and Parasympatholytic drugs. d) Sympathomimetic and sympatholytic drugs. e) Skeletal muscle relaxants (peripheral and central). f) Drugs used in the treatment of myasthenia gravis and glaucoma

UNIT 2

Pharmacology of drugs acting on the cardiovascular system a) Introduction to cardiovascular hemodynamic and cardiac electrophysiology. b) Drugs used in congestive cardiac failure. c) Anti-arrhythmic drugs. d) Anti-anginal and newer anti-ischemic drugs. e) Anti-hypertensive drugs. f) Shock, types of shocks and drugs used in their management. g) Stroke, types of strokes and drugs used in their management

UNIT 3

Pharmacology of drugs acting on blood and kidney 1.Pharmacology of drugs acting on blood a) Anti-platelet agents b) Coagulants and anticoagulants. c) Fibrinolytics and Plasma expanders. d) Haematinics. e) Anti-hyperlipidaemic drugs. 2. Pharmacology of drugs acting on kidney a) Diuretics. b) Anti-diuretics.

UNIT 4

Pharmacology of autacoids and related drugs a) Introduction to autacoids and their classification. Therapeutic significance of important agonists and antagonists of prostaglandins, thromboxane, leukotrienes, angiotensin, bradykinin and substance P. b) Histamine and antihistamines. c) 5-HT, its agonists and antagonists, drugs used in migraine. d) Non-steroidal anti-inflammatory drugs, antipyretics and analgesics. e) Anti-gout and Antirheumatic drugs including Disease Modifying Antirheumatic Drugs (DMARDs).

UNIT 5

i) Pharmacology of Drugs acting on respiratory system a) Drugs used in the treatment of bronchial asthma and COPD. b) Definitions, classification and therapeutic uses of nasal decongestants, mucolytics, expectorants and antitussives. c) Respiratory stimulants. ii) Pharmacology of Drugs acting on immune system Mechanism of action, adverse effects and therapeutic uses of important classes of immune stimulants and immunosuppressants.